Dr. Petruzziello was born and raised in Rome, Italy. While completing a residency in General Surgery, he served as Medical Officer in the Mounted State Police with a rank of First Lieutenant and appointed to care for the President of Italy and his Security Service.

He moved to the United States in 1995, where he entered the Internal Medicine residency program at the University of Massachusetts. In 1998 he moved to Connecticut and co-founded Family Practice and Internal Medicine of Spring Glen. In 2007 Dr. Petruzziello established a new medical practice: Family Practice and Internal Medicine (CareMedica), along with two associated medical enterprises: Lasermedica Dermacenters USA (LaserMedica) and Medical Weight Professionals (WeightMedica).

Dr. Petruzziello has authored more than 30 research articles in the fields of Gastrointestinal Surgery, Antibiotic Therapy and Geriatric Medicine, published in Italian and other international journals. He is a member of the American Medical Association, the American College of Physicians, the Connecticut State Medical Society and the New Haven County Medical Society.

He lives in North Haven with his wife and three children.